2022 NFC Championship Game odds, picks, line: 49ers vs. Rams predictions, best bets by top expert who’s 10-1

SoFi Stadium hosts the biggest football game in its history on Sunday evening. The Los Angeles Rams host the San Francisco 49ers in the 2022 NFC Championship Game, and the game is the third matchup between the division rivals this season. San Francisco is 2-0 against Los Angeles and 9-2 in its last 11 games. The Rams, meanwhile, are 7-1 in their last eight games with a 14-5 overall record between the regular season and playoffs.

Kick-off is at 6:30 p.m. ET in Los Angeles. Caesars Sportsbook lists the Rams as 3.5-point home favorites, while the Over-Under, or total number of points Vegas thinks will be scored, is 45.5 in the latest 49ers vs. Rams odds. Before you make any Rams vs. 49ers picks and NFC Championship Game predictions, make sure you check out what SportsLine’s resident 49ers expert, Micah Roberts, has to say.

Roberts has worked in the Las Vegas sportsbook industry for 20-plus years, including a 13-year run as Station Casinos’ book director. He is 10-6 against the spread in his last 16 NFL picks for a profit of $345. 

In addition, Roberts has gone an astounding 10-1 in his last 11 picks involving San Francisco. Anyone who has followed him is way up.

Now, Roberts has set his sights on 49ers vs. Rams, and just locked in his coveted picks and NFL playoff predictions. You can head to SportsLine now to see his picks. Here are several NFL lines and trends for 49ers vs. Rams:

• 49ers vs. Rams spread: Rams -3.5 
• 49ers vs. Rams over-under: 45.5 points 
• 49ers vs. Rams money line: Rams -175, 49ers +150
• SF: The 49ers are 9-2 against the spread in their last 11 games 
• LAR: The Rams are 6-2 against the spread in their last eight games