Cardinals vs. Colts odds, spread, line: 2021 NFL on Christmas picks, Week 16 prediction by model on 133-96 run

The Arizona Cardinals are hoping last week’s loss at Detroit was a wake-up call as they take on the Indianapolis Colts in an important interconference matchup on NFL Christmas Day 2021. The Cardinals (10-4), who had the No. 1 seed in the NFC playoff picture just three weeks ago, have lost two straight and now find themselves as the No. 4 seed heading into the weekend. The Colts (8-6), who were all but left for dead in the AFC postseason race, are now back in the thick of things after back-to-back wins over Houston and New England.

Kickoff from State Farm Stadium in Glendale, Ariz., is set for 8:15 p.m. ET. Arizona is a three-point favorite in the latest Cardinals vs. Colts odds from Caesars Sportsbook, while the over-under for total points scored is 48. Before you make any Colts vs. Cardinals bets, make sure to check out the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up over $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 16 of the 2021 season on an incredible 133-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Colts vs. Cardinals 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see its picks. Here are several NFL odds and betting trends for Colts vs. Cardinals:

• Colts vs. Cardinals spread: Cardinals -3
• Colts vs. Cardinals over-under: 48 points
• Colts vs. Cardinals money line: Indianapolis +140, Arizona -160
• IND: Colts are 4-0 against the spread in their last four games as road underdogs
• ARI: Cardinals…