NFL

NFL Week 1 picks, predictions, schedule, odds, fantasy tips

6 September، 2025

20 1 minute read

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The Week 1 NFL schedule for the 2025 season brings some exciting matchups. The Lions take a trip to Lambeau Field, the 49ers and Seahawks face off in an NFC West showdown, and a must-see QB duel between Lamar Jackson and Josh Allen will be held in Buffalo.

We have you covered with everything you need to know. Our NFL Nation reporters take you inside the locker room with the best thing they heard this week, and ESPN Research provides a key stat to know and a betting nugget for each contest. Plus, analytics writer Seth Walder makes a bold prediction for each matchup, and fantasy analyst Eric Moody shares fantasy football intel. We also have Football Power Index (FPI) matchup quality ratings (out of 100) and game projections, and three analysts — Pamela Maldonado, Moody and Walder — give us final score picks for every game.

Let’s get into the full Week 1 slate, which culminates with the “Monday Night Football” matchup between the Vikings and Bears on ESPN. (Game times are Sunday unless otherwise noted.)

Thursday: PHI 24, DAL 20
Friday: KC-LAC

1 p.m. ET | Fox | Matchup rating: 43.9/100
ESPN BET: WSH -6.5 (45.5 O/U)

What we’re hearing on the Giants: The Giants lost a lot last season, including both matchups with the Commanders by a total of eight points. That gave Washington quarterback Jayden Daniels bragging rights over his former college teammate and best friend, Giants wide receiver Malik Nabers. It didn’t sit well with Nabers, who is tired of all the losing. “I was like, ‘Enough is enough,'” Nabers said. “‘I’m coming to get you.'” He and the Giants have a chance at redemption in Week 1. — Jordan Raanan

What we’re hearing on the Commanders: The Commanders know they’re facing a front seven that, as offensive coordinator Kliff Kingsbury said, is “as challenging as we’ll face.” The Giants sacked Daniels five times…

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