NFL Week 5 picks, schedule, odds, injuries, stats, fantasy tips

The Week 5 NFL schedule for the 2022 season is stacked with great matchups, and we have you covered with what you need to know heading into the weekend. Our NFL Nation reporters bring us the biggest keys to every game and a bold prediction for each matchup.

Additionally, ESPN Stats & Information provides a big stat to know and a betting nugget for each contest, and our Football Power Index (FPI) goes inside the numbers with a matchup rating (on a scale of 1 to 100) and a game projection. ESPN researcher Kyle Soppe hands out helpful fantasy football intel, as well. Finally, Seth Walder and Eric Moody give us final score picks for every game. Everything you want to know is here in one spot to help you get ready for a loaded weekend of NFL football.

Let’s get into the full Week 5 slate, including another London showdown (Giants-Packers), Kenny Pickett’s first start, Jalen Hurts vs. Kyler Murray and an AFC North meeting between the Bengals and Ravens. It all culminates with a Monday Night Football matchup between the Raiders and the Chiefs on ESPN. (Game times are Sunday unless otherwise noted.)

Jump to a matchup:
NYG-GB | ATL-TB | PIT-BUF
DET-NE | CHI-MIN | MIA-NYJ
LAC-CLE | SEA-NO | TEN-WSH
HOU-JAX | SF-CAR | PHI-ARI
DAL-LAR | CIN-BAL | LV-KC

Thursday: IND 12 DEN 9

9:30 a.m. ET | NFL Network
Spread: GB -8.0 (41)

What to watch for: This could be a nightmare matchup for the Packers’ defense. It ranks in the bottom third of the NFL in yards allowed per carry (5.0), and the Giants — with the NFL’s leading rusher, Saquon Barkley — run it at the second-best clip in the league (5.8 yards per carry). It prompted Packers coach Matt LaFleur to say this week that defensive coordinator Joe Barry needs to have his players “play more physical” and “in certain situations you might have to put an extra defender in the box.” — Rob Demovsky

Bold prediction: Aaron Rodgers throws for 300-plus yards and at least three touchdowns. Rodgers hasn’t topped 255 yards passing this season, and the…